Difference between revisions of "Antibiotic Responsive Diarrhoea"

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*motility disorders
 
*motility disorders
  
The effect of ARD are:
+
The consequence of ARD are:
 
*interferance with fluid and nutritional absorption due to dysfunction of the enzymes located at the microvillous.
 
*interferance with fluid and nutritional absorption due to dysfunction of the enzymes located at the microvillous.
 
*disturbance in mucosal permeability.
 
*disturbance in mucosal permeability.

Revision as of 14:47, 17 August 2009



Category:WikiClinical CanineCow
Category:WikiClinical FelineCow


Signalment

  • Common in young German Shepherd Dogs


Description

Antibiotic responsive diarrhoea (ARD) used to be termed as small intestinal bacterial overgrowth (SIBO). It is a sign of an underlying disease rather than a diagnosis. The aetiology and pathogenesis of this disease is unknown. Few studies have documented the scale of increase in bacterial numbers or whether the growth is responsible for the clinical signs.

ARD can be claasified as idiopathic or secondary. In cases of idiopathic ARD, the only consistent finding is response and remission on antimicrobial therapy. In contrast, there is usually an underlying intestinal disease in cases of secondary ARD. Diseases which affect any of the following functions of the intestines can cause secondary ARD:

  • decreased gastric acid production
  • increased small intestinal substrate
  • partial obstructive disorders
  • anatomical disorders
  • motility disorders

The consequence of ARD are:

  • interferance with fluid and nutritional absorption due to dysfunction of the enzymes located at the microvillous.
  • disturbance in mucosal permeability.
  • deconjugation of bile acids.
  • hydroxylation of fatty acids.

Diagnosis

Clinical Signs

Laboratory Tests

Haematology

Biochemistry

Other Tests

Diagnostic Imaging

Histopathology

Treatment

Prognosis

References

  • Ettinger, S.J. and Feldman, E. C. (2000) Textbook of Veterinary Internal Medicine Diseases of the Dog and Cat Volume 2 (Fifth Edition) W.B. Saunders Company.
  • Hall, E.J, Simpson, J.W. and Williams, D.A. (2005) BSAVA Manual of Canine and Feline Gastroenterology (2nd Edition) BSAVA
  • Nelson, R.W. and Couto, C.G. (2009) Small Animal Internal Medicine (Fourth Edition) Mosby Elsevier.