Difference between revisions of "Bovine Herpesvirus 1"

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**[[Respiratory Viral Infections - Pathology#Infectious bovine rhinotracheitis (IBR)|'''Infectious bovine rhinotracheitis (IBR)''']]
  
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====Antigenicity====
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===Antigenicity===
 
*Two different viruses:
 
*Two different viruses:
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**[[Respiratory Viral Infections - Pathology#Infectious bovine rhinotracheitis (IBR)|'''Infectious bovine rhinotracheitis (IBR)''']]: aerosol transfer
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**'''Infectrious Pustular Vulvovaginitis (IPV)''': venereal transfer
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[[Infectious Bovine Rhinotracheitis]]
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[[Infectious Pustular Vulvovaginitis]]
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Also known as IPV
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Caused by:[[Bovine Herpesvirus 1]]
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: venereal transfer
  
 
====Pathogenesis====
 
====Pathogenesis====
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'''IBR''':
 
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*BHV-1 infects the respiratory mucosal epithelial cells (intranuclear inclusion eosinophilic inclusion bodies)from nasal mucosa down to bronchioles
 
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**Leading to neutrophilic inflammation of varying severity: serous -> catarrhal -> purulent nasal discharge, sneezing, coughing
 
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*Dypsnoea, anorexia
 
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*Rhinotracheitis that can develop into bronchopneumonia
 
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*Clinical signs include coughing, discharge, lacrimation, and increased respiratory rate
 
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*Clinical disease most severe in young calves - can develop mucosal ulcerative lesions in the oesophagus and forestomachs and viraemia with multiorgan infection
 
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*Generally high morbidity, low mortality, but up to 75% mortality if concurrent with [[Bovine Virus Diarrhoea Virus|BVDV]], caused by meningo-encephalitis
 
  
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'''IPV''':
 
 
*Painful genital lesions
 
*Painful genital lesions
 
*Impaired reproductive performance
 
*Impaired reproductive performance
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***ELISA for gE deletion can enable culling of carrier animals
 
***ELISA for gE deletion can enable culling of carrier animals
 
*IPV has mostly been made obsolete by AI
 
*IPV has mostly been made obsolete by AI
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[[Category:Herpesviridae]]

Revision as of 10:18, 22 May 2010


 This article is still under construction.


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VIRUSES
HERPESVIRUSES



Antigenicity

  • Two different viruses:

Infectious Bovine Rhinotracheitis


Infectious Pustular Vulvovaginitis

Also known as IPV Caused by:Bovine Herpesvirus 1

venereal transfer

Pathogenesis

  • Painful genital lesions
  • Impaired reproductive performance
  • Frequent micturition

Diagnosis

  • Virus isolation and immunofluorescence

Control

  • Vaccination:
    • Two live attenuated vaccines are available in the UK, one is temperature-sensitive
      • Both given intranasally
      • Neither protect against re-infection when given during clinical outbreak, but can lessen the severity of the disease
    • Inactivated vaccines: intranasal/intramuscular administration
      • gE deletion makes this a marker vaccine
      • ELISA for gE deletion can enable culling of carrier animals
  • IPV has mostly been made obsolete by AI
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