Difference between revisions of "Shigella"

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*Not significant cause of infection in domestic animals
 
*Not significant cause of infection in domestic animals
*Causes [[Intestine Pathogens - Pathology#Dysentery in Humans and Primates|dysentery in humans and primates]]
+
*Causes dysentery in humans and primates
 
*Enteroinvasive, invading the intestinal mucosa and causing necrosis
 
*Enteroinvasive, invading the intestinal mucosa and causing necrosis
 
*Do not cause systemic disease - they do not invade beyond the lamina propria to the bloodstream
 
*Do not cause systemic disease - they do not invade beyond the lamina propria to the bloodstream

Revision as of 11:26, 6 June 2010

  • Not significant cause of infection in domestic animals
  • Causes dysentery in humans and primates
  • Enteroinvasive, invading the intestinal mucosa and causing necrosis
  • Do not cause systemic disease - they do not invade beyond the lamina propria to the bloodstream
  • A large plasmid permits survival in cells and is responsible for invasivenss
  • Closely related to E. coli - some strains produce Shiga toxin which is related to vero cytotoxin of E. coli
  • Cause of dysentery in humans and primates.

Dysentery in Humans and Primates

  • Shigella is are enteroinvasive,
    • Penetrate the intestinal mucosa.
    • Cause necrosis in patches of mucosa.
  • Shigella do not invade beyond the lamina propria to the bloodstream.
  • Invasive potential is carried by a large plasmid.
    • Relates to the ability to survive inside the host cells.
  • Some strains produce Shiga toxin.
    • Related to vero cytotoxin of some pathogenic strains of E.coli.