Author, Bureaucrats, Administrators
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===Type II reactions===
===Type II reactions===
*Cytotoxic reaction
*Cytotoxic reaction
*IgG and IgM interaction with antigens bound to cellular membranes
*IgG and [[IgM]] interaction with antigens bound to cellular membranes
*Often involves [[Complement#Complement Fixation Pathways|complement fixation]] -> cellular damage
*Often involves [[Complement#Complement Fixation Pathways|complement fixation]] -> cellular damage
*In skin - circulating antibody to proteins of desmosomes in intercellular areas along basement membranes at epidermal-dermal junction
*In skin - circulating antibody to proteins of desmosomes in intercellular areas along basement membranes at epidermal-dermal junction
===Type III reactions===
===Type III reactions===
*[[Complement#Complement Fixation Pathways|Complement fixing]] immune complexes
*[[Complement#Complement Fixation Pathways|Complement fixing]] immune complexes
*IgG or IgM
*IgG or [[IgM]]
*Complexes deposit in tissue -> fix complement -> cytokines and othe factors attrack neutrophils -> release lysosomal enzymes, activation of complement and coagulation, platelet aggregation -> tissue damage
*Complexes deposit in tissue -> fix complement -> cytokines and othe factors attrack neutrophils -> release lysosomal enzymes, activation of complement and coagulation, platelet aggregation -> tissue damage
*Immune complex vasculitis -> [[Haemorrhage - Pathology#Purpura haemorrhagica|purpura haemorrhagica]]
*Immune complex vasculitis -> [[Haemorrhage - Pathology#Purpura haemorrhagica|purpura haemorrhagica]]