Author, Bureaucrats, Administrators
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===Type I reactions===
===Type I reactions===
*Mediated by pharmacologically active substances from [[Mast Cells|mast cells]] and [[Basophils|basophils]]
*Mediated by pharmacologically active substances from [[Mast Cells|mast cells]] and [[Basophils|basophils]]
**Due to antigen-antibody (usually IgE) binding to receptors on those cells
**Due to antigen-antibody (usually [[IgE]]) binding to receptors on those cells
*Substances include histamine, serotonin, leukotriens, prostaglandins
*Substances include histamine, serotonin, leukotriens, prostaglandins
*Can be systemic or local
*Can be systemic or local