Difference between revisions of "Category:Primary Immunodeficiency"

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[[Primary Innate Immunity Deficiencies]]
 
[[Primary Innate Immunity Deficiencies]]
 +
[[Primary Adaptive Immunity Deficiencies]]
  
===Deficiencies of Adaptive Immunity===
 
 
====Equine Severe Combined Immune Deficiency (Equine SCID)====
 
*Autosomal recessive
 
*Occurs in 2-3% of Arabian foals
 
*Defect in DNA-dependent protein kinase gene
 
**Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of [[Lymphocytes|lymphocytes]] (e.g. Ig and TCR)
 
*No functional [[Lymphocytes#B cells|B cells]] or [[Lymphocytes#T cells|T cells]]
 
*Foals develop infections (usually around 8 weeks of age as maternal [[Immunoglobulins|antibody]] in [[Materno-Fetal Immunity - Introduction#Passive transfer via colostrum|colostrum]] wanes around this time)
 
*Foals usually die from bronchopneumonia
 
 
====Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)====
 
*Affects Basset Hounds and Corgis
 
*X-linked recessive defect in the gene coding for the IL-2 receptor
 
**IL-2 receptor is a receptor for the cytokine IL-2 which causes [[Lymphocytes#T cells|T cells]] to proliferate
 
*Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
 
*Animal usually dies from pneumonia or sepsis as the level of maternal [[Immunoglobulins|antibody]] decreases
 
 
====Selective [[IgA]] deficiency of German Shepherd Dogs====
 
*Poorly understood
 
*Linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis
 
*[[Immunoglobulin A|[[IgA]]]] deficiency so more susceptible to mucosal disease
 
 
====Immunodeficiency of Weimaraners, Irish Wolfhounds and Miniature Dachshunds====
 
*Unknown aetiology
 
*Inherited defects
 
*Low levels of circulating [[Immunoglobulin M|IgM]] and [[Immunoglobulin G|IgG]]
 
*Impaired [[Neutrophils|neutrophil]] function
 
*Causes recurrent pyrexia and infections
 
**E.g. Rhinitis and bronchopneumonia in Irish Wolfhounds due to low [[Immunoglobulin A|[[IgA]]]]
 
**E.g. Pneumocytosis in Miniature Dachshunds due to low [[Immunoglobulin G|IgG]]
 
  
 
===Laboratory Examples of Severe Combined Deficiency===
 
===Laboratory Examples of Severe Combined Deficiency===

Revision as of 13:52, 12 August 2010

  • Primary immunodeficiencies may affect either the innate immune system or the adaptive immune system
  • They are categorised by either the type or the developmental stage of the cells involved
  • Lymphoid cell disorders affect T cells or B cells (or both)
  • Myeloid cell disorders affect phagocytic function
  • The severity of the immunodeficiency depends on at which stage in development the problem occurs
    • E.g. Defects early on in development will affect the entire immune system
  • T cell deficiencies can affect both the cell-mediated and humoral response as T cells play a central role in the immune system

Primary Innate Immunity Deficiencies Primary Adaptive Immunity Deficiencies


Laboratory Examples of Severe Combined Deficiency

Athymic Nude Mouse - Armin Kübelbeck 2008
  • Severe Combined Immune Deficiency(SCID)
  • Athymic nude mice (no thymus)
    • No functional T cells
    • Cell-mediated immunodeficiency
  • Knock-out mice
    • E.g. Gene coding for CD4, CD8, IL-10 removed

Subcategories

This category has the following 2 subcategories, out of 2 total.

Pages in category "Primary Immunodeficiency"

This category contains only the following page.