Difference between revisions of "Category:Primary Adaptive Immunity Deficiencies"

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====[[Equine Severe Combined Immune Deficiency]] ====
 
====[[Equine Severe Combined Immune Deficiency]] ====
  
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====Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)====
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====[[Canine X-Linked Severe Combined Immune Deficiency]] ====
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*Affects Basset Hounds and Corgis
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*X-linked recessive defect in the gene coding for the IL-2 receptor
 
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**IL-2 receptor is a receptor for the cytokine IL-2 which causes [[Lymphocytes#T cells|T cells]] to proliferate
 
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*Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
 
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*Animal usually dies from pneumonia or sepsis as the level of maternal [[Immunoglobulins|antibody]] decreases
 
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[[Category:Primary Adaptive Immunity Deficiencies]]
 
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[[Category:To Do - Blood]]
 
 
====Selective [[IgA]] deficiency of German Shepherd Dogs====
 
====Selective [[IgA]] deficiency of German Shepherd Dogs====
 
*Poorly understood
 
*Poorly understood
 
*Linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis
 
*Linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis
 
*[[Immunoglobulin A|[[IgA]]]] deficiency so more susceptible to mucosal disease
 
*[[Immunoglobulin A|[[IgA]]]] deficiency so more susceptible to mucosal disease
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[[Category:Primary Adaptive Immunity Deficiencies]]
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[[Category:Primary Adaptive Immunity Deficiencies]][[Category:Dog]]
 
[[Category:To Do - Blood]]
 
[[Category:To Do - Blood]]
 
====Immunodeficiency of Weimaraners, Irish Wolfhounds and Miniature Dachshunds====
 
====Immunodeficiency of Weimaraners, Irish Wolfhounds and Miniature Dachshunds====
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**E.g. Pneumocytosis in Miniature Dachshunds due to low [[Immunoglobulin G|IgG]]
 
**E.g. Pneumocytosis in Miniature Dachshunds due to low [[Immunoglobulin G|IgG]]
  
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[[Category:Primary Adaptive Immunity Deficiencies]]
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[[Category:Primary Adaptive Immunity Deficiencies]][[Category:Dog]]
 
[[Category:To Do - Blood]]
 
[[Category:To Do - Blood]]
  

Revision as of 13:55, 12 August 2010

Deficiencies of Adaptive Immunity

Equine Severe Combined Immune Deficiency

Canine X-Linked Severe Combined Immune Deficiency

Selective IgA deficiency of German Shepherd Dogs

  • Poorly understood
  • Linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis
  • [[Immunoglobulin A|IgA]] deficiency so more susceptible to mucosal disease

Immunodeficiency of Weimaraners, Irish Wolfhounds and Miniature Dachshunds

  • Unknown aetiology
  • Inherited defects
  • Low levels of circulating IgM and IgG
  • Impaired neutrophil function
  • Causes recurrent pyrexia and infections
    • E.g. Rhinitis and bronchopneumonia in Irish Wolfhounds due to low [[Immunoglobulin A|IgA]]
    • E.g. Pneumocytosis in Miniature Dachshunds due to low IgG
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