Difference between revisions of "B cells"
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<p>So named as they were initially found in the [[Bursa of Fabricius - Anatomy & Physiology|Bursa of Fabricius]]. They produce antibodies (Ig’s) and are associated with humoral immunity. They represent 20-30% of circulating lymphocytes. | <p>So named as they were initially found in the [[Bursa of Fabricius - Anatomy & Physiology|Bursa of Fabricius]]. They produce antibodies (Ig’s) and are associated with humoral immunity. They represent 20-30% of circulating lymphocytes. | ||
B cells have B cell receptors (BCR), or antigen binding sites. This is [[IgM]] when the B cell is immature, changing to [[IgD]] when the cell is mature. B cells also express MHC II, CD9, CD,19, CD20 and CD24.</p> | B cells have B cell receptors (BCR), or antigen binding sites. This is [[IgM]] when the B cell is immature, changing to [[IgD]] when the cell is mature. B cells also express MHC II, CD9, CD,19, CD20 and CD24.</p> | ||
| − | <p>Under antigenic stimulation they differentiate into [[B cell differentiation | + | <p>Under antigenic stimulation they differentiate into [[B cell differentiation#Plasma cells|plasma cells]] and [[B cell differentiation#Memory cells|memory cells]].</p> |
B-cells also act as Antigen-Presenting Cells (APCs) by presenting digested fragments to T-cells on [[MHC - WikiBlood#MHC II|MHC II]]. | B-cells also act as Antigen-Presenting Cells (APCs) by presenting digested fragments to T-cells on [[MHC - WikiBlood#MHC II|MHC II]]. | ||
| − | For more on B cell differentiation, see [[B cell differentiation | + | For more on B cell differentiation, see [[B cell differentiation|here]]. |
[[Category:Lymphocytes|C]] | [[Category:Lymphocytes|C]] | ||
Revision as of 14:34, 13 August 2010
Also called B lymphocytes
So named as they were initially found in the Bursa of Fabricius. They produce antibodies (Ig’s) and are associated with humoral immunity. They represent 20-30% of circulating lymphocytes. B cells have B cell receptors (BCR), or antigen binding sites. This is IgM when the B cell is immature, changing to IgD when the cell is mature. B cells also express MHC II, CD9, CD,19, CD20 and CD24.
Under antigenic stimulation they differentiate into plasma cells and memory cells.
B-cells also act as Antigen-Presenting Cells (APCs) by presenting digested fragments to T-cells on MHC II.
For more on B cell differentiation, see here.