Difference between revisions of "Equine Severe Combined Immune Deficiency"
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m (Text replace - "[[Lymphocytes|" to "[[Lymphocytes - Introduction|") |
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*Occurs in 2-3% of Arabian foals | *Occurs in 2-3% of Arabian foals | ||
*Defect in DNA-dependent protein kinase gene | *Defect in DNA-dependent protein kinase gene | ||
| − | **Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of [[Lymphocytes|lymphocytes]] (e.g. Ig and TCR) | + | **Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of [[Lymphocytes - Introduction|lymphocytes]] (e.g. Ig and TCR) |
*No functional [[Lymphocytes#B cells|B cells]] or [[Lymphocytes#T cells|T cells]] | *No functional [[Lymphocytes#B cells|B cells]] or [[Lymphocytes#T cells|T cells]] | ||
*Foals develop infections (usually around 8 weeks of age as maternal [[Immunoglobulins|antibody]] in [[Materno-Fetal Immunity - Introduction#Passive transfer via colostrum|colostrum]] wanes around this time) | *Foals develop infections (usually around 8 weeks of age as maternal [[Immunoglobulins|antibody]] in [[Materno-Fetal Immunity - Introduction#Passive transfer via colostrum|colostrum]] wanes around this time) | ||
Revision as of 12:41, 18 August 2010
(Equine SCID)
- Autosomal recessive
- Occurs in 2-3% of Arabian foals
- Defect in DNA-dependent protein kinase gene
- Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of lymphocytes (e.g. Ig and TCR)
- No functional B cells or T cells
- Foals develop infections (usually around 8 weeks of age as maternal antibody in colostrum wanes around this time)
- Foals usually die from bronchopneumonia