Difference between revisions of "Equine Severe Combined Immune Deficiency"
Jump to navigation
Jump to search
m (Text replace - "Category:To Do - Blood" to "Category:To Do - BloodCategory:To Do - Clinical") |
|||
| Line 8: | Line 8: | ||
*Foals usually die from bronchopneumonia | *Foals usually die from bronchopneumonia | ||
[[Category:Primary Adaptive Immunity Deficiencies]] | [[Category:Primary Adaptive Immunity Deficiencies]] | ||
| − | [[Category:To Do - Blood]][[Category:To Do - | + | [[Category:To Do - Blood]][[Category:To Do - SophieIgnarski]] |
[[Category:Horse]] | [[Category:Horse]] | ||
Revision as of 17:06, 23 August 2010
(Equine SCID)
- Autosomal recessive
- Occurs in 2-3% of Arabian foals
- Defect in DNA-dependent protein kinase gene
- Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of lymphocytes (e.g. Ig and TCR)
- No functional B cells or T cells
- Foals develop infections (usually around 8 weeks of age as maternal antibody in colostrum wanes around this time)
- Foals usually die from bronchopneumonia