Difference between revisions of "Canine Brucellosis"

Revision as of 10:31, 13 September 2010

Description

Canine brucellosis is caused by the intracellular gram negative bacteria B. canis. The disease predominantly affects the reproductive system causing abortion and infertility in females and epididymitis and infertility in males. Other systems can also be affected, causing uveitis, discospondylitis, dermatitis and osteomyelitis. Transmission to humans has been documented but is very rare.

Animals are infected when the organism gains entry to the body at mucus membranes: vaginal, oral and conjunctival. Macrophages then phagocytose B. canis which targets lymphoid and genital tissue. A transient lymphoid hyperplasia and hyperglobinemia develop in the early stages of infection followed by a bactereamia 1-4 weeks post initial infection which can persist for up to 5 years. Brucellosis is transmitted by females at oestrus, breeding, post abortion, transplacentaly and is shed in urine, faeces and milk. Males shed the organism in semen for up to 2 years and in urine for up to 3 months. A cell mediated immune response is needed to clear the organism, however non-protective antibody may develop which complicates diagnosis and treatment of the disease.

Signalment

The prevalence of brucellosis is relatively low (1-8% in the U.S); areas affceted include the U.S, Japan, South America, Spain, Tunisia and Germany. The disease is more common in stray animals and breeding kennels. There is no breed susceptibility reported but beagles are over represented in cases in the U.S. The disease usually affects sexually mature animals and females more than males.

Diagnosis

Clinical Signs

Female:

Abortion
Postabortion vaginal discharge
Early embryonic loss

Male:

Scrotal enlargement
Epididymitis
Seminal abnormalities
Testicular atrophy
Infertility

- Abortions, decreased fertility, reduced litter sizes, neonatal mortality
- Orchitis and epididymitis causing infertility in male dogs
- Infertility may be permanent if chronic infection

Laboratory Tests

- Slide agglutination, ELISA, agar gel immunodiffusion

Treatment

- Neuter infected animals

Prognosis

References

Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial
Nelson, R.W. and Couto, C.G. (2009) Small Animal Internal Medicine (Fourth Edition) Mosby Elsevier
Tilley, L.P. and Smith, F.W.K.(2004)The 5-minute Veterinary Consult (Third edition) Lippincott, Williams & Wilkins

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 Canine brucellosis is caused by the intracellular gram negative bacteria ''B. canis''. The disease predominantly affects the reproductive system causing abortion and infertility in females and epididymitis and infertility in males. Other systems can also be affected, causing uveitis, discospondylitis, dermatitis and osteomyelitis. Transmission to humans has been documented but is very rare.
-Animals are infected when the organism gains entry to the body at mucus membranes: vaginal, oral and conjunctival. Macrophages then phagocytose ''B. canis'' which targets lymphoid and genital tissue. A transient lymphoid hyperplasia and hyperglobinemia develop in the early stages of infection followed by a bactereamia 1-4 weeks post initial infection which can persist for up to 5 years. A cell mediated immune response is needed to clear the organism, however non-protective antibody may develop which complicates diagnosis and treatment of the disease.
+Animals are infected when the organism gains entry to the body at mucus membranes: vaginal, oral and conjunctival. Macrophages then phagocytose ''B. canis'' which targets lymphoid and genital tissue. A transient lymphoid hyperplasia and hyperglobinemia develop in the early stages of infection followed by a bactereamia 1-4 weeks post initial infection which can persist for up to 5 years. Brucellosis is transmitted by females at oestrus, breeding, post abortion, transplacentaly and is shed in urine, faeces and milk. Males shed the organism in semen for up to 2 years and in urine for up to 3 months. A cell mediated immune response is needed to clear the organism, however non-protective antibody may develop which complicates diagnosis and treatment of the disease.
 ==Signalment==