Difference between revisions of "Urticaria"
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==Pathogenesis== | ==Pathogenesis== | ||
| − | The aetiopathogenesis of urticaria is complex and many causes have been suggested. The basic pathogenesis is thought to be due to degranulation of mast cells and basophils leading to the release of inflammatory mediators and an increase in vascular permeability. Other hypotheses include exogenous or endogenous hypersensitivity reactions. Exogenous urticaria may occur due to chemicals, medication | + | The aetiopathogenesis of urticaria is complex and many causes have been suggested. The basic pathogenesis is thought to be due to degranulation of mast cells and basophils leading to the release of inflammatory mediators and an increase in vascular permeability. Other hypotheses include exogenous or endogenous hypersensitivity reactions. Exogenous urticaria may occur due to chemicals, medication and insect bites or stings. Endogenous urticaria occurs due to inhalation of allergens. |
| + | |||
==Signalment== | ==Signalment== | ||
| − | Horses between 1 and 10 years of age are most prone to developing the condition. There is no sex predilection but Thoroughbreds and Arabs | + | Horses between 1 and 10 years of age are most prone to developing the condition. There is no sex predilection but Thoroughbreds and Arabs appear to be more commonly affected than other breeds. |
==History and clinical signs== | ==History and clinical signs== | ||
| − | Multiple wheals are often observed with urticaria and occur within a few minutes or hours of exposure to the causative agent. A history of recurrence or repeated episodes is often reported. Affected areas can vary from small, localised lesions up to 3cm in diameter, to extensive generalised areas involving large areas of skin. Lesions can occur on any part of the body but usually develop on the back, legs, flanks, neck and eyelids. Pruritus may or may not be present. | + | Multiple wheals are often observed with urticaria and occur within a few minutes or hours of exposure to the causative agent. A history of recurrence or repeated episodes is often reported. Affected areas can vary from small, localised lesions up to 3cm in diameter, to extensive generalised areas involving large areas of skin. Lesions can occur on any part of the body but usually develop on the back, legs, flanks, neck and eyelids. In severe cases the mucous membranes of the nose, mouth, anus and vulva may be involved. Pruritus may or may not be present and the lesions usually disappear rapidly. |
==Diagnosis== | ==Diagnosis== | ||
| − | Because of the numerous underlying causes of urticaria, definitive diagnosis may be difficult. Historical and clinical findings may lead to the suspicion of urticaria. The localisation of lesions (e.g. site of contact with saddle or insect repellent) may help to determine an underlying cause | + | Because of the numerous underlying causes of urticaria, definitive diagnosis may be difficult. Historical and clinical findings may lead to the suspicion of urticaria. The localisation of lesions (e.g. site of contact with saddle or insect repellent) or history of medication of exposure to chemicals may help to determine an underlying cause. |
| − | + | ==Treatment== | |
| + | Acute urticaria usually resolves spontaneouly without requiring treatment. Dexamethasone given once at a dose of 0.1 mg/kg IM usually results in resolution of clinical signs within 24 hours. Recurrent cases may require further investigation in order to determine the underlying cause. This may include further investigation of the animal's history and response to withdrawal of drugs or topical products. | ||
| + | ==References== | ||
| + | *Mair, T. S., Love, S., Schumacher, J., Watson, A. E. (1998) '''Equine Medicine, Surgery and Reproduction''' ''Elsevier Health Sciences'' | ||
*Pascoe, R. R., Knottenbelt, D. C. (1999) '''Manual of Equine Dermatology''' ''Elsevier Health Sciences'' | *Pascoe, R. R., Knottenbelt, D. C. (1999) '''Manual of Equine Dermatology''' ''Elsevier Health Sciences'' | ||
| + | *Rose, R. J., Hodgson, D. R. (2000) '''Manual of Equine Practice''' ''Elsevier Health Sciences'' | ||
*Scott, D. W., Miller, W. H. (2003) '''Equine Dermatology''' ''Elsevier Health Sciences'' | *Scott, D. W., Miller, W. H. (2003) '''Equine Dermatology''' ''Elsevier Health Sciences'' | ||
[[Category:Allergic Skin Diseases]] | [[Category:Allergic Skin Diseases]] | ||
[[Category:To Do - Blood]][[Category:To Do - SophieIgnarski]] | [[Category:To Do - Blood]][[Category:To Do - SophieIgnarski]] | ||
Revision as of 11:02, 19 September 2010
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This article is still under construction. |
Description
Urticaria is a condition of the skin characterised by multiple oedematous swellings (wheals) that dent or 'pit' with digital pressure. It occurs in all domestic animals but most commonly in the horse.
Pathogenesis
The aetiopathogenesis of urticaria is complex and many causes have been suggested. The basic pathogenesis is thought to be due to degranulation of mast cells and basophils leading to the release of inflammatory mediators and an increase in vascular permeability. Other hypotheses include exogenous or endogenous hypersensitivity reactions. Exogenous urticaria may occur due to chemicals, medication and insect bites or stings. Endogenous urticaria occurs due to inhalation of allergens.
Signalment
Horses between 1 and 10 years of age are most prone to developing the condition. There is no sex predilection but Thoroughbreds and Arabs appear to be more commonly affected than other breeds.
History and clinical signs
Multiple wheals are often observed with urticaria and occur within a few minutes or hours of exposure to the causative agent. A history of recurrence or repeated episodes is often reported. Affected areas can vary from small, localised lesions up to 3cm in diameter, to extensive generalised areas involving large areas of skin. Lesions can occur on any part of the body but usually develop on the back, legs, flanks, neck and eyelids. In severe cases the mucous membranes of the nose, mouth, anus and vulva may be involved. Pruritus may or may not be present and the lesions usually disappear rapidly.
Diagnosis
Because of the numerous underlying causes of urticaria, definitive diagnosis may be difficult. Historical and clinical findings may lead to the suspicion of urticaria. The localisation of lesions (e.g. site of contact with saddle or insect repellent) or history of medication of exposure to chemicals may help to determine an underlying cause.
Treatment
Acute urticaria usually resolves spontaneouly without requiring treatment. Dexamethasone given once at a dose of 0.1 mg/kg IM usually results in resolution of clinical signs within 24 hours. Recurrent cases may require further investigation in order to determine the underlying cause. This may include further investigation of the animal's history and response to withdrawal of drugs or topical products.
References
- Mair, T. S., Love, S., Schumacher, J., Watson, A. E. (1998) Equine Medicine, Surgery and Reproduction Elsevier Health Sciences
- Pascoe, R. R., Knottenbelt, D. C. (1999) Manual of Equine Dermatology Elsevier Health Sciences
- Rose, R. J., Hodgson, D. R. (2000) Manual of Equine Practice Elsevier Health Sciences
- Scott, D. W., Miller, W. H. (2003) Equine Dermatology Elsevier Health Sciences