CNS Congenital Abnormalities - Pathology

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Introduction

  • Congenital malformations may involve the spinal cord, brain, meninges, calvaria or vertebral column.
  • Abnormalities typically result from defects in neural tube development.
  • Congenital malformations are present at or before birth, and manifest as either:
    • Morphological problems
    • Functional problems
      • Tend to arise as biochemical abnormalities, such as the lysosomal diseases or leukodystrophies.
  • Causes of congenital abnormalities include:
    • Environmental causes
      • For example, these may be toxic, infectious, nutritional, or physical (e.g. radiation)
      • This is by far the most common cause.
    • Inherited traits.

Meningoencephalocoele

Hydrocephalus

Cerebellar Defects