Aldosterone
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BACK TO DISTAL TUBULE
Overview
- Steroid hormone
- Secreted from the zona glomerulosa of the adrenal cortex of the adrenal gland
- Mineralocorticoid
- Most important regulator of plasma pottassium
- Stimulated directly by increased plasma pottassium
- Also stimulated as part of the Renin-Angiotensin-Aldosterone System (RAAS)
Action
- Works by altering gene transcription
- Affects ATP levels
Sodium
- Affects sodium entry and transport
- Increases sodium re-uptake to a small degree in distal convoluted tubule
Pottassium and Hydrogen
- Causes pottassium and hydrogen secretion
- Pottassium via apical leak channels
- Hydrogen by proton secretory proteins