Vaccines

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BACK TO IMMUNOLOGY
BACK TO HOST INVASION BY MICROORGANISMS

Why Vaccinate?

  • To protect against infectious diseases
  • Where there is no effective treatment once infected
    • E.g. FeLV, FIV
  • Where disease is life-threatening
    • E.g. Canine Parvovirus
  • To prevent the spread of disease
    • E.g. Rabies, FMDV

How do we vaccinate?

  • Usually by subcutaneous injection for systemic protection (IgG)
  • For mucosal immune reponse, intranasal administration is best (IgA)

What do we vaccinate with?

Passive immunisation

  • Administer antibodies
    • Maternally-derived antibodies in colostrum
    • Antiserum (artificial)
  • Immediate protection
  • Short duration of action

Active immunisation

  • Administer antigen so the patient's own antibodies protect against disease
    • Living organisms
    • Dead organisms
    • Toxoids
    • Subunit antigens
    • DNA
  • Delay in protection
  • Often needs two or more doses
  • Long duration of action

What antigens do we use in the vaccine?

Links

Creators

Natalie Brown