Gastric Ulceration - Dog

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Signalment

Description

There are many disease associations including:

Causes of gastric ulceration
Disease Type E.g.
Hypotension Shock, Sepsis
Drug - induced Non-steroidal anti-inflammatory drugs (NSAIDs)
Idiopathic Stress, exercise induced
Inflammatory Gastritis
Neoplastic Adenocarcinoma, lymphosarcoma, leiomyoma
Metabolic/endocrine Hypoadrenocorticism, liver disease, uraemia, disseminated intravascular coagulation, mastocytosis and hypergastrinaemia

Gastric ulceration is caused by damage to the gastric mucosa through the above mechanisms. NSAIDs directly damage the mucosa and interfere with the prostaglandin synthesis. Gastric ulceration is worsened by the use of NSAIDs in combination with corticosteroids. This risk can be minimised by using cyclooxygenase-1 (COX-1) sparing NSAIDs (carprofen, meloxicam and deracoxib.

Gastric acid hypersecretion following mast cell degranulation of histamine and gastrin secretion from gastrinomas is a major cause of gastric ulceration. Sled dogs and equine race horses are prone to gastric ulceration.

Diagnosis

History and Clinical Signs

History may involve:

  • Access to toxins and drugs such as NSAIDs

Clinical Signs:

  • Vomiting
  • Haematemesis
  • Malaena
  • Pale mucous membranes
  • Abdominal pain
  • Weakness
  • Inappetance
  • Hypersalivation
  • Circulatory comprimise

Haematology

Biochemistry

Urinalysis

Plain radiography

Positive Contrast Radiography

Ultrasonography

Endoscopy and Biopsy

Treatment

Fluid therapy

Acid-base correction

Mucosal protectants

Prophylaxis

Anti-emetics

Analgesia

Antibiotics

Surgery

Prognosis

Depends upon the cause

References