Category:Enteritis, Proliferative

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Paratuberculosis (Johne's Disease)

Proliferative Enteritis in Other Species

Colitis, Granulomatous

Porcine Adenomatosis Complex

  • Characteristic proliferation of mucosa.
  • Known as PIA - porcine intestinal adenomatosis.

Clinical

  • Really only seen in the pig.
    • Can affect all ages of pig.
  • Clinical signs are variable.
    • Anything from poor weight gain to diarrhoea, weight loss, cachexia and death.
  • Seen often as problem in closed, low infection herds.
    • Not seen in pigs with lots of other pathogens in guts.

Pathogenesis

Pathology

  • The terminal small intestine and colon are affected by proliferation of the mucosal epithelium.
  • Gross
    • Thickened mucosal epithelium.
    • Has almost polypoid-like nodules several millimetres in diameter.
    • Undifferentiated epithelium replaces goblet cells.
      • Appears almost neoplastic.
  • Histologically
    • Very similar to a virus induced proliferation.
    • Organisms seen in the apical part of epithelial cells lining glands of terminal ileum, colon and caecum.
    • May produce mild ulceration in mucosa and mild inflammatory infiltration.


  • Porcine adenomatosis complex can be divided into four distinct syndromes:
    1. Intestinal adenomatosis
      • THe basic hyperplastic and metaplastic changes are seen in the epithelium.
        Campylobacter mucosalis in intracellular porcine intestinal adenomatosis (Courtesy of Bristol BioMed Image Archive)
      • Causes chronic weight loss and diarrhoea.
    2. Necrotic enteritis
      • Predominately affects the colon and terminal ileum.
      • Parts of the hyperplastic mucosa develop erosions and ulcerations.
        • These areas become colonised by Fusiformis baceria.
          • Gives areas of coagulative necrosis covered by a thick diptheretic membrane.
    3. Terminal ileitis
      • Characterised by marked hypertrophic thickening of the muscular portion of the wall of the terminal ileum.
      • Gives an attendant stenosis of the lumen of the ileum.
      • There is associated thickening of the mucosa due to hypertrophy and secondary granulomatous inflammation.
        • This is presumably caused by a degree of obstruction to the passage of ingesta along the bowel caused by the mucosal hypertrophy.
      • Appears very similar to Johnes disease
        • Lots of mononuclear cells and a chronic granulomatous type of inflammation.
    4. Proliferative haemorrhagic syndrome.
      • The bowel shows proliferation but with ulceration and copious haemorrhage into the bowel lumen.
      • Animals are often be found dead.
      • The pathogenesis is unclear.
        • May involve a type of hypersensitivity reaction or secondary infection of some type.

Sequelae

  • Resolution.
  • Necrotic enteritis.
  • Secondary chronic infection (regional enteritis).
  • Porcine haemorrhgaic enteritis (PHE).

Pages in category "Enteritis, Proliferative"

The following 3 pages are in this category, out of 3 total.