Haemangiosarcoma

Description

A highly malignant tumour of vascular endothelial origin. They commonly affect dogs and the most frequently affected areas are the spleen, pericardium, right atrium, liver and muscle. The cat is affected less frequently and the most common sites are the liver, spleen and mesentry. Metastasis occurs via the haematogenous route or via rupture and transabdominal spread. Metastatic sites include, lungs, liver, omentum and diaphram.

Signalment

Often found in older German Shepherd Dogs and Golden Retrievers. Domestic Short haired cats are the most commonly affected cat breed.

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  Golden Retriever

  Monika Mężyńska (2005); WikiMedia Commons

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  German Shepherd (Alsatian)

  Ellen Levy Finch (22/02/04); WikiMedia Commons

History and Clinical Signs

Can vary depending on the anatomic site that the mass is affecting. Signs such as anorexia, lethargy, weakness, vomiting and anaemia are common. Animals can also present Collapsed; due to rupture of the mass, leading to a haemoabdomen or occasionally be found dead.

In instances where the heart is involved animals may present in heart failure. If there is muscularinvolvement this often presents as a hard swollen mass. If the nervous sytem is involved a range of neurological abnormalities will also be present.

Laboratory Tests

Haematology

Anaemia; may be regenerative if due to blood loss, or microangiopathic due to the passage of red blood cells through the microvascular network of the tumour

Diagnostic Imaging

Radiography

This may be able to reveal any masses, provided there is minimal peritoneal fluid.

Ultrasonography

This is sensitive in indentifying liver and splenic masses.

Pathology

Cholangiocellular - bile duct

• can be primary in the liver
• other predilection sites
  • spleen
  • right auricle of the heart
• prevalent in large breeds

From Spleen Pathology

distinguished from the superficially similar haemangioma by the presence of much more formed, solid tumour tissue

• accurate prognosis demands histological examination
• secondaries are common locally in the omentum and in the liver

The course of disease is usually short, often only a month or two and metastases may occur in almost every organ.

Histopathology

Biopsy of any masses will provide a definitive diagnosis. This is needed to differentiate haemangiosarcoma from splenic haematoma, haemangioma and accessory splenic tissue.

Treatment

Surgery

This is useful if there are any solitary masses that can be excised.

Chemotherapy

This will provide a palliative treatment for animals with multiple masses or as an adjuvant therapy post-operatively.

Prognosis

Poor due to high risk of metastasis in the early course of the disease.

References

Ettinger, S.J. and Feldman, E. C. (2000) Textbook of Veterinary Internal Medicine Diseases of the Dog and Cat Volume 2 (Fifth Edition) W.B. Saunders Company.

Hall, E.J, Simpson, J.W. and Williams, D.A. (2005) BSAVA Manual of Canine and Feline Gastroenterology (2nd Edition) BSAVA

Nelson, R.W. and Couto, C.G. (2009) Small Animal Internal Medicine (Fourth Edition) Mosby Elsevier.