Feline Infectious Anaemia

Also known as: Haemobartonellosis

Caused by: Mycoplasma haemofelis also known as Haemobartonella felis

Mycoplasma haemofelis
Phylum	Firmicutes
Class	Mollicutes
Order	Mycoplasmatales
Family	Mycoplasmataceae
Genus	Mycoplasma
Species	M.haemofelis

Description

An infectious disease of the cat caused by Mycoplasma haemofelis which until recently was known as Haemobartonella felis. It is a species of the Mycoplasmas genus which causes Feline Infectious Anaemia.

The organism is found on the surface of erythrocytes and is considered an opportunistic infection that causes illness following predisposing factors. It is possible to be transmitted via bite wounds, biting arthropods, via blood transfusions and from a queen to her kittens. The organism causes a cyclic parasitaemia in affected cats and infected animals, despite mounting an immune response, will become carriers of the organism.

Signalment

Almost half of the cats infected have concurrent Feline Leukaemia Virus (FeLV).

The disease is common in roaming Tom cats 1-3 years old.

Clinical signs

The peracute disease is associated with severe anaemia and immunosuppression, and can be rapidly fatal.

Fever, anaemia, depression, weakness and jaundice occur in the acute form. In the chronic form animals present with anaemia, lethargy and weight loss.

Cyclic fever may also occur during the transient period of parasitaemia.

Recovery can occur with a regenerative bone marrow response, however severe anaemia may occur in the presence of feline leukaemia virus (FeLV).

Diagnosis

The best diagnostic test is a PCR, which is very sensitive and enables differentiation of the different species.

The organism can also be diagnosed on blood smears. The organism can be intermittently seen microscopically on the surface of red blood cells on Giemsa-stained blood smears. The organism stains blue and can look like rings or rods.

Erythrophagocytosis may be evident and parasitised erythrocytes will become spherical.

The organism must be differentiated from Howell-Jolly bodies and other parasites. Due to the cyclic parasitaemia the organism causes, negative blood smears will not rule out the disease.

Additionally Immunofluorescence of blood smears can demonstrate the organism.

Haematology will show a decreased packed cell volume and a low red blood cell count. The anaemia is usually regenerative. FeLV infection is associated with macrocytosis.

Treatment

Infected cats should be treated with doxycycline for 3 weeks twice daily. Enrofloxacin is also a good treatment choice especially in refractory cases when combined with doxycycline.

A blood transfusion may also be required in cases of severe anaemia.

As blood sucking endoparasites, such as Fleas, are thought to spread disease the animal should also receive flea treatment.

Prednisolone is also advised to treat the immune mediated mechanisms and to prevent further erythrophagocytosis.

Prognosis

Varied prognosis depending on the severity of the anaemia at presentation. If not treated 1/3 of affected animals will die. Antibiotics do not clear the infection so many cats become carriers of the organism however relapses are uncommon.

References

Ettinger, S.J, Feldman, E.C. (2005) Textbook of Veterinary Internal Medicine (6th edition, volume 2)W.B. Saunders Company

Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial