Arrhythmogenic Right Ventricular Cardiomyopathy - Feline Cardiomyopathies

Overview

Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a rare form of cardiomyopathy in cats and is more commonly seen in humans and dogs. ARVC is characterised by fibrofatty infiltration replacement of cardiomyocytes predominantly in the right ventricle and right atrium; this may also effect the left ventricle to a lesser degree in some cases. Pathophysiological sequelae include severe right ventricular myocardial failure, life-threatening ventricular arrhythmias and sudden death.

Aetiology

Little is known about he cause of ARVC in cats. In humans and Boxer dogs, ARVC is caused by mutations in various components of the desmosome (necessary for cell-cell adhesion). The resultant loss of mechanical coupling predisposes to arrhythmias.

Pathophysiology

Reduced myocardial contractility predominantly involves the right ventricle. This results in reduced stroke volume and increased ventricular filling pressure due to increased end-systolic ventricular diameter. This eventually leads to congestive heart failure (CHF).

Clinical Signs

Signalment

There is no breed or sex predilection. Mean age at the time of diagnosis was 7.3 +/- 5.2 years in one case series of 11 cats.

Physical Examination

The majority of cats present with signs referable to right-sided CHF. Other clinical findings include:

• Soft right parasternal pansystolic murmur, due to tricuspid regurgitation
• Syncope
• Lethargy
• Anorexia

Right-sided Congestive Heart Failure

• Tachypnoea
• Jugular vein distension, jugular pulses
• Hepatojugular reflux
• Ascites
• Hepatomegaly

Arrhythmias

Cats with ARVC may present with arrhythmias including ventricular tachycardia, atrial fibrillation, atrial standstill, supraventricular tachycardia, ventricular premature complexes, right bundle branch block and AV block.