Clostridium perfringens type B
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- Lamb dysentery
- Up to 30% morbidity and high mortality
- Affects lambs in first week of life
- Abdominal distension, pain, bloody faeces, sudden death
- Bacterial overgrowth in the intestine of the lamb due to immature bacterial flora
- Lack of proteases in the immature gut prevents cleavage of the beta toxin, allowing it to cause disease
- Also alpha and epsilon toxins
- Haemorrhagic enteritis and ulceration in the small intestine
- Fluid in the peritoneal cavity and pericardial sac due to increased capillary permeability (beta toxin)
- Fatal haemorrhagic enteritis in newborn foals, calves and adult goats