Permethrin Toxicity
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Introduction
Permethrin is the active ingredient of many 'spot-on' paraciticides used in the control of fleas and ticks in dogs [1]. In is also used in products intended for use in rats, mice, gerbils and guinea pigs [1]. Permethrin mediates its effects through modulation of voltage-sensitive sodium channels. Cite error: Closing </ref> missing for <ref> tag.
Diagnosis
Clinical Signs
Laboratory Tests
Pathology
The spot-on canine preparations are often quite concentrated.[1]. Cats lack the enzyme glucuronidase transferase [2] and is therefore unable to utilise the metabolic pathway that dogs and other animals use to break down permethrin into glucuronides and sulphates [1]
Treatment
Prognosis
References
- ↑ 1.0 1.1 1.2 1.3 Clinical effects and outcome of feline permethrin spot-on poisonings reported to the Veterinary Poisons information Service (VPIS), London, Journal of Feline Medicine and Surgery(2007)9,335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 Cite error: Invalid
<ref>tag; name "multiples" defined multiple times with different content Cite error: Invalid<ref>tag; name "multiples" defined multiple times with different content Cite error: Invalid<ref>tag; name "multiples" defined multiple times with different content - ↑ Whittem 1995 Pyrethrin and pyrethroid insecticide intoxication in cats.Compendium of Continuing Education for the Veterinary Practitioner 17 489-492, referenced in Journal of Feline Medicine and Surgery(2007)9,335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010