Calcium Hydroxylapatite Deposition Disease

• Gt Dane puppies with paraplegia
• Calcium phosphate depositon has been reported in multiple diarthrodial joints of the axial and appendicular skeleton

More about Calcium hydroxylapatite deposition disease:

[Calcium hydroxylapatite deposition disease in a Great Dane puppy. Wunschmann A. et al. Vet Path (2000) 37 346-9]

• This case
  • Calcium hydroxyapatite deposition in the axial skeleton and included marked fibrocartilagenous proliferation resulting in compression of the cervical cord
  • 10wk old Gt Dane
  • Ca2+ and Phosphorous serum levels normal
  • May get skeletal malformations secondary to the deposition of the mineral in the joint (starts on the articular facets of cervical vertebrae)
  • In humans, associated with point mutation in type II procollagen gene
  • ?Underlying cause