Idiopathic Polyradiculoneuritis

Immune mediated demyelination often involving roots, directed against unknown epitopes in peripheral myelin.

May be post infection

May get axonal injury if severe

As for distal denervating (although more rapid onset)

May have sensory involvement.

By clinical signs

CSF changes if roots involved

Slower nerve conduction

H reflexes and F-waves may be lost

Very good prognosis

Recovery in 3-6 weeks by remyelination

Immunosuppresive levels of corticosteroids (although may delay remyelination)