Gastric Ulceration - Dog

See also Pathology in WikiPath

Signalment

• Sled dogs

Description

Is a round or oval punched out lesions ranging from 1-4 cm in diameter caused by damage to the gastric mucosa.

There are many disease associations including:

Disease type	E.g.
Hypotension	Shock, Sepsis
Drug - induced	Non-steroidal anti-inflammatory drugs (NSAIDs)
Idiopathic	Stress, exercise induced
Inflammatory	Gastritis
Neoplastic	Adenocarcinoma, lymphosarcoma, leiomyoma
Metabolic/endocrine	Hypoadrenocorticism, liver disease, uraemia, disseminated intravascular coagulation, mastocytosis and hypergastrinaemia

Gastric ulceration is caused by damage to the gastric mucosa through the above mechanisms. NSAIDs directly damage the mucosa and interfere with the prostaglandin synthesis. Gastric ulceration is worsened by the use of NSAIDs in combination with corticosteroids. This risk can be minimised by using cyclooxygenase-1 (COX-1) sparing NSAIDs (carprofen, meloxicam and deracoxib.

Gastric acid hypersecretion following mast cell degranulation of histamine and gastrin secretion from gastrinomas is a major cause of gastric ulceration. Sled dogs and equine race horses are prone to gastric ulceration.

Diagnosis

History and Clinical Signs

History may involve:

• Access to toxins and drugs such as NSAIDs

Clinical Signs:

• Vomiting
• Haematemesis
• Malaena
• Pale mucous membranes
• Abdominal pain
• Weakness
• Inappetance
• Hypersalivation
• Circulatory comprimise

Haematology

• Anaemia - regenerative initially, may progress to microcytic, hypochromic and minutely regenerative.
• Thrombocytosis
• Lack of stress leucogram (and lymphocytosis and eosinophilia) supportive of hypoadrenocorticism
• Examination of the buffy coat may detect mastocytosis
• Neutrophilia and a left shift - signs of inflammation or gastric perforation
• May show abnormalities in haemostasis

Biochemistry

• Dehydration - azotaemia
• Hepatic disease - increased liver enzymes and bilirubin, decreased urea, albumin and cholesterol
• Renal disease - azotaemia
• Hypoadrenocorticism - Sodium:Potassium ratio of less than 27:1
• Vomiting will lead to electrolyte and acid-base abnormalities - metabolic alkalosis, hypokalaemia and hypochloraemia

Urinalysis

• Dehydration - Hypersthenuria
• Renal disease - Isosthenuria

Plain radiography

Not usually diagnostic but rules out differentials.

Positive Contrast Radiography

May show filling defects.

Ultrasonography

Shows gastric thickening and rules out differentials.

Endoscopy and Biopsy

Diagnostic test of choice and allows biopsies to be taken. NSAID related ulcers are reguarly located in the antrum and there is limited mucosal thickening or irregularity whereas ulcerated gastric tumours will have thickened mucosa and edges. Any biopsies should be taken at the edge of normal and diseased to avoid further deepening or perforation.

Treatment

The main aim is to treat any primary underlying cause whilst giving general support. This may be hydrating, restoring electrolytes and acid-base and also helping the gastric lining to recover.

Fluid therapy

Depends upon degree of dehydration, prescence of shock and any other diseases that are affected by volume. Prolonged vomiting or anorexia may lead to hypokalaemia so KCl may need adding to any fluids given. Normal rates for treatment of shock apply with dehydration being overcome by a fluid rate over 24 hours to replace the defecits along with a maintenance rate.

Acid-base correction

Imbalances should be corrected after taking a blood gas reading.

• If metabolic acidotic: give sodium bicarbonate (1mmol/kg), but do repeated blood gas
• If metabolic alkalosis: replace volume defecit with intravenous NaCl and KCl.
• Blocking of acid secretion:
  • Histamine receptor antagonists:
    • cimetidine
    • ranitidine
    • famotidine
  • Gastrin antagonists:
    • proglumide
  • Acetylcholine receptor antagonists:
    • atropine
    • pirenzepine
  • Adenyl cyclase inhibitors:
    • Prostaglangin E2 (PGE) analogues
  • H:K ATPase inhibitors
    • omeprazole

Analgesia

Is best provided by opiods such as buprenorphine, pethidine and fentanyl.

Surgery

May be required to investigate or to resect peforating ulcers which may lead to peritonitis.

Prognosis

Depends upon the cause

References

Hall, J.E., Simpson, J.W. and Williams, D.A., (2005) BSAVA Manual of Canine and Feline Gastroenterology (2nd Edition) BSAVA