Villus atrophy with intact/hypertrophic crypt glands

• Insult affects the villus enterocytes leading to increased loss.
  • Under mild insult, villi may fully regenerate.
  • Severe insult leads to immature cells on the villus.
    • Secrete water and electrolytes into lumen.
• Examples include:
  • Rotavirus, Coronavirus
    • Infect villus enterocytes.
  • Coccidia
    • Infect surface enterocytes.
  • Nematodes
    • Abrase surface.