- adenovirus - Canine Adenovirus 1
- also known as Rubarth's Disease, Canine adenovirus infection
- acute and generalised infection
- young dogs
- highly infectious
- spread via the urine of infected animals over a long period of time
Clinical
- lymph nodes and tonsils are enlarged and reddened, sometimes haemorrhagic
- recovering animals may show an immune-mediated uveitis with corneal opacity
Gross
- the virus has a tropism for endothelium and hepatocytes
- widespread haemorrhages, especially on serosal surface
- distinctly pale mottled appearance
- from extensive necrosis, characteristically periacinar (centrilobular) in distribution - the reason for the increased susceptibility of this area is not known
- enlarged
- friable
- fibrinous or fibrino-haemorrhagic strands between lobes
- gall bladder
- wall usually shows oedema (up to 2cm diameter)
Microscopically
- basophilic intranuclear inclusion bodies
- in hepatocytes and macrophages