Category:Primary Innate Immunity Deficiencies

Deficiencies of Innate Immunity

Appearance of a puppy with Grey Collie syndrome - Copyright Michelle Tennis & Peggy Melton

Canine Cyclic Haematopoiesis

• Also called Grey Collie Syndrome
• Autosomal recessive
• Insertion mutation in AP3B1 gene
• Diluted grey coat colour, stunted growth, poor wound healing
• Neutropenia every 2 weeks which lasts 3-4 days due to cyclic production of cells from bone marrow
• Animals are prone to recurrent infections, mainly from the respiratory and gastrointestinal tract
  • E.g. pyrexia, diarrhoea, gingivitis and arthritis
• Puppies can be distinguished from other litter mates by the diluted grey colouring
• Affected puppies show symptoms such as fever, joint pain and eye, skin and respiratory infections from 8 weeks of age
• Affected animals rarely live beyond 2-3 years with most puppies dying within a few weeks of birth

Canine Leukocyte Adhesion Deficiency (CLAD)

• Occurs in Irish Setters
• Missence mutation of -Cys-36-Ser- in CD18 molecule
  • CD18 is required for neutrophil migration and phagocytosis
• Recurrent bacterial infection
• Neutrophilia (neutrophils remain in the blood and are unable to fight infection in the tissue)

Bovine Leukocyte Adhesion Deficiency (BLAD)

• Occurs in Holstein cattle
• Missence mutation of -Asp-128-Gly in CD18 molecule
• Recurrent infection, e.g. pneumonia

[[Category:Primary Im