Glycogen Storage Disease

• Caused by a deficiency of an enzyme
• See general pathology
• Type II glycogenosis
  • Deficiency of acid maltase
  • In Shorthorn cattle
  • Muscular weakness and incoordination
  • Glycogen stored in skeletal muscle, heart and CNS
  • Type I and II muscle fibres contain glycogen vacuoles
• Type III glycogenosis
  • Deficiency of debranching enzyme
  • In dogs
  • Causes hypertrophic cardiomyopathy and hepatomegaly
  • Glycogen in skeletal and cardiac muscle, neurons nad hepatocytes