Glycogen Storage Disease

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  • Caused by a deficiency of an enzyme
  • See general pathology
  • Type II glycogenosis
    • Deficiency of acid maltase
    • In Shorthorn cattle
    • Muscular weakness and incoordination
    • Glycogen stored in skeletal muscle, heart and CNS
    • Type I and II muscle fibres contain glycogen vacuoles
  • Type III glycogenosis
    • Deficiency of debranching enzyme
    • In dogs
    • Causes hypertrophic cardiomyopathy and hepatomegaly
    • Glycogen in skeletal and cardiac muscle, neurons nad hepatocytes