Severe Combined Deficiency - Laboratory Examples

Athymic Nude Mouse - Armin Kübelbeck 2008

• Severe Combined Immune Deficiency(SCID)
  • No functional B cells or T cells

• Athymic nude mice (no thymus)
  • No functional T cells
  • Cell-mediated immunodeficiency

• Knock-out mice
  • E.g. Gene coding for CD4, CD8, IL-10 removed