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Liver - Anatomy & Physiology (view source)

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==Histology==

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[[Image:Lobule Histology.jpg|thumb|right|~~150px~~|Liver Lobule Histology - Copyright RVC 2008]]

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[[Image:Lobule Histology.jpg|thumb|right|250px|Liver Lobule Histology - Copyright RVC 2008]]

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*Connective tissue capsule around each lobule

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The larger liver cells are called '''lobules'''. Each lobule contains an opening for the '''central vein'' and contains portal areas. The lobules are composed of liver cords called '''hepatocytes'''. Sinusoids are present between hepatocytes containing red blood cells. There is a connective tissue capsule around each liver lobule. A thin '''mesothelium''' covers the connective tissue layer.

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*Thin mesothelium covers connective tissue layer

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The '''portal area''' present in the lobules contains the '''hepatic artery''', which has thick walls and a small diameter and the '''hepatic vein''', which has thin walls and a large and irregular shape. It also contains '''bile ducts''', with cuboidal or columnar epithelium and '''lymphatics''' that are small and delicate.

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[[Image:Portal Triad Histology.jpg|thumb|right|250px|Portal Triad Histology in a Lobule- Copyright RVC 2008]]

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*The larger liver cells ~~are called~~ lobules

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'''Hepatocytes''' are the smaller liver cells in the lobules. They contain glycogen granules and have a spherical nucleus. They form cords called '''branching plates''' (lamellae). The upper and lower margins are tight junctions. They have 3 functioning surfaces. '''Kupfer macrophages''' are present near the lining of the sinusoids. The hepatocytes tain pink as they are '''eosinophilic'''.

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**Each lobule contains an opening for the central vein and ~~contains portal areas~~

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**Lobules composed of liver cords called ~~hepatocytes~~

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**Sinusoids present ~~between~~ hepatocytes ~~containing red blood cells~~

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*Portal area present in lobules

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**Hepatic artery- thick walls, small diameter

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**Hepatic vein- thin walls, large and irregular shape

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**Bile ducts- cuboidal or columnar epithelium

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**Lymphatics- small and delicate

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~~[[Image:Portal Triad Histology.jpg|thumb|right|150px|Portal Triad Histology in a Lobule- Copyright RVC 2008]]~~

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*Hepatocytes are the smaller liver cells in the lobules

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**Contain glycogen granules

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**Stain pink as are eosinophilic

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**Spherical nucleus

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**Forms cords called branching plates (lamellae)

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**Upper and lower margins are tight junctions

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**3 functioning surfaces

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***Adjacent to sinusoid contains microvilli

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***Between adjacent cells are smooth

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***Adjacent cells have short microvilli, membranes diverge, explanded intracellular spaces and bile canaliculi

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*Kupfer macrophages present near the lining of the sinusoids

===Acinus===

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