Changes

****End result in muscle consisting of almost only fibrous tissue  

****End result in muscle consisting of almost only fibrous tissue  

***Sometimes replaced by fat tissue -> increased size of muscle = ''pseudohypertrophy''

***Sometimes replaced by fat tissue -> increased size of muscle = ''pseudohypertrophy''

***Muscle may have a mixture of atrophied and [[Muscles Hyperplastic and Neoplastic - Pathology#Hypertrophy|hypertrophied]] (due to increased work load) fibres if some motor units are not damaged

***Muscle may have a mixture of atrophied and [[Muscle Hypertrophy|hypertrophied]] (due to increased work load) fibres if some motor units are not damaged

**<u>'''Metabolisation of muscle protein'''</u> for nutrients during:

**<u>'''Metabolisation of muscle protein'''</u> for nutrients during:

***Malnutrition, cachexia, senility

***Malnutrition, cachexia, senility

***Gradual onset except for some febrile diseases causing cachexia

***Gradual onset except for some febrile diseases causing cachexia

***Postural muscles are not affected, sometimes even [[Muscles Hyperplastic and Neoplastic - Pathology#Hypertrophy|hypertrophy]]

***Postural muscles are not affected, sometimes even [[Muscle Hypertrophy|hypertrophy]]

***Histologically:

***Histologically:

****Some nuclei disappear as myofibre volume is decreased

****Some nuclei disappear as myofibre volume is decreased