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CNS Inflammation - Pathology
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Revision as of 12:53, 8 March 2011
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===[[Granulomatous Meningoencephalitis]]===
===[[Granulomatous Meningoencephalitis]]===
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(GME)
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* An [[CNS Idiopathic Conditions - Pathology|idiopathic CNS conditon]]
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* May occur as:
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** A disseminated disease
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** A focal mass lesion
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** A primary occular disease
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* Brainstem signs are common, although the forebrain is primarily affected.
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* May be incorrectly diagnosed as lymphoma.
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* Changes are apparent in the CSF.
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** There is usually a mononucloear pleocytosis.
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** Sometimes only protein is elveated.
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* Diffuse inflammatory changes or a mass lesion will be seen by advanced imaging.
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** However, biopsy is required for a definative diagnosis.
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* Life span is between 6 months and 1 year from diagnosis.
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====Treatment====
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[[Necrotising Meningoencephalitis]]
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* Immunosuppression:
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** Corticosteroids
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** Azathioprine
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** Cycophosphamide
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* Surgery
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** This is only appropriate if there is a focal mass.
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* Radiation therapy.
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[[Necrotising Meningoencephalitis]]
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[[:Category:CNS Non-Infectious Inflammatory Diseases]]
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