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== Causes ==
== Introduction ==
Hepatocytic necrosis can occur following severe metabolic disturbances, toxic substances, nutritional deficiencies and through the action of micro-organisms.
Hepatocytic necrosis can occur following severe metabolic disturbances, toxic substances, nutritional deficiencies and through the action of micro-organisms.
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[[Liver - Anatomy & Physiology|Liver]] cell necrosis has been classified on an anatomic basis with reference to the distribution of the lesion.
[[Liver - Anatomy & Physiology|Liver]] cell necrosis has been classified on an anatomic basis with reference to the distribution of the lesion.
== Random foci (focal)==
Microscopic foci of necrosis are not related to any particular part of the liver lobule and can be due to a variety of insults such as, systemic viral, bacterial and parasitic infections and as a result of bacteria being absorbed from the gut.
Microscopic foci of necrosis is not related to any particular part of the [[Liver - Anatomy & Physiology|liver]] lobule and can be due to a variety of insults such as, systemic viral, bacterial and parasitic infections and as a result of bacteria being absorbed from the gut.
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Examples include
Examples include
*Equine herpes virus infection; necrosis found in aborted foetuses.
*[[Equine Herpesvirus 1|Equine herpes virus]] infection; necrosis found in aborted foetuses.
*Salmonellosis; necrosis found in the liver of calves due to the S. dublin serotype.
*[[Salmonellosis]]; necrosis found in the liver of calves due to the ''S. dublin'' serotype.
*Toxoplasmosis (miliary necrosis), which is found in affected dogs and cats.
*[[Toxoplasmosis - Cat and Dog|Toxoplasmosis]] (miliary necrosis), which is found in affected dogs and cats.
======Periacinar (centrilobular)======
== Zonal necrosis ==
Zonal necrosis is necrosis occurring mainly in a part of the lobule and further subdivided according to whether the lesions are situated centrally, peripherally, or in the mid-zone of the lobule:
===Periacinar (centrilobular)===
This is the most common type of zonal necrosis and occurs mainly due to the fact that the hepatocytes in this zone are furthest away from the incoming blood supply and are therefore less oxygenated and relatively anoxic. They are reported to contain the greatest number of enzymes responsible for metabolising substances to more toxic metabolites capable of killing the hepatocytes. Therefore hypoxic states and toxic substances predominate in this type of necrosis, although some viral conditions also are the cause, such as '''[[Infectious Canine Hepatitis]] (ICH)'''. This is a highly infectious disease of young dogs which is spread by urine. It is now rare due to vaccination in the UK.
===Midzonal===
Midzonal necrosis is rare and is mainly seen in pigs with alfatoxicosis. It is also seen in humans suffering from 'Yellow Fever'.
Midzonal necrosis is rare and is mainly seen in pigs with aflatoxicosis. It is also seen in humans suffering from 'Yellow Fever'.
======Periportal (centroacinar)======
======Periportal (centroacinar)======
Centroacinar necrosis is also rare. This has been seen in cases of phosphorous poisoning.
Centroacinar necrosis is also rare. This has been seen in cases of phosphorous poisoning.
=== Massive necrosis ===
=== Massive necrosis ===
This occurs when there is necrosis of a complete acinus or an even larger area of tissue. It encompasses large areas of [[Liver - Anatomy & Physiology|liver]] cells comprising many lobules (complete acinus or several acini) and sometimes involving almost the whole organ.
This occurs when there is necrosis of a complete acinus or an even larger area of tissue. It encompasses large areas of liver cells comprising many lobules (complete acinus or several acini) and sometimes involving almost the whole organ.
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It can occur is some cases of ICH infection or carbon tetrachloride poisoning, with the severity of the injury replacing the zonal pattern.
It can occur is some cases of ICH infection or carbon tetrachloride poisoning, with the severity of the injury replacing the zonal pattern.
==Subacute cytolytic necrosis==
This is a condition in the dog, of which the aetiology is entirely unknown. Clinical symptoms include acute abdominal pain, collapse and invariably jaundice. Pathology shows the liver is normal or reduced in size and that there is severe necrosis.
======Subacute cytolytic necrosis======
==''Hepatosis dietica''==
This is a condition in the dog, of which the aetiology is entirely unknown. Clinical symptoms include acute abdominal pain, collapse and invariably jaundice. Pathology shows the [[Liver - Anatomy & Physiology|Liver]] is normal or reduced in size and that there is severe necrosis.
This is a similar condition to subacute cytolytic necrosis, but it occurs in rapidly growing pigs. It is thought to be related to diet and occurs in pigs fed on large quantities of grain concentrates, poor quality or low quantity protein supplements. This results in nutritional deficiencies of selenium and Vitamin E, and probably amino acids. It is thought to be triggered by stress.
======''Hepatosis dietica''======
==Test yourself with the Liver Pathology Flashcards==
[[Liver_Flashcards_-_Pathology|Liver Pathology Flashcards]]
== References ==
== References ==
Blood, D.C. and Studdert, V. P. (1999) Saunders Comprehensive Veterinary Dictionary (2nd Edition), Elsevier Science.
Blood, D.C. and Studdert, V. P. (1999) '''Saunders Comprehensive Veterinary Dictionary '''(2nd Edition),'' Elsevier Science.''
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Ettinger, S.J, Feldman, E.C. (2005) Textbook of Veterinary Internal Medicine (6th edition, volume 2), W.B. Saunders Company.
Ettinger, S.J, Feldman, E.C. (2005) '''Textbook of Veterinary Internal Medicine '''(6th edition, volume 2),'' W.B. Saunders Company.''
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Fossum, T. W. et. al. (2007) Small Animal Surgery (Third Edition), Mosby Elsevier.
Fossum, T. W. et. al. (2007) '''Small Animal Surgery''' (Third Edition),'' Mosby Elsevier.''
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Nelson, R.W. and Couto, C.G. (2009) Small Animal Internal Medicine (Fourth Edition), Mosby Elsevier.
Nelson, R.W. and Couto, C.G. (2009) '''Small Animal Internal Medicine '''(Fourth Edition)'', Mosby Elsevier. ''
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[[Category:Liver_-_General_Pathology]]
[[Category:Liver_-_General_Pathology]]
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