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Intervertebral Disc Degeneration (view source)
Revision as of 18:43, 9 October 2007
, 18:43, 9 October 2007no edit summary
**Probably partly because all are chondrodysplastic to a varying degree
**Probably partly because all are chondrodysplastic to a varying degree
***Occurs in all disks simultaneously (cf: non chondrodysplastic dogs – degeneration in only one disk at a time).
***Occurs in all disks simultaneously (cf: non chondrodysplastic dogs – degeneration in only one disk at a time).
**Chondrodysplastic dogs -> chondroid metaplasia of the nucleus pulposus, with progressive calcification
***Occurs at a young age … cf non-chondrodysplastic breeds , occurs as a senile change
***Occurs at a young age … cf non-chondrodysplastic breeds , occurs as a senile change
***Progressive decrease in amount of glycosaminoglycans, and changes from chondroitin sulphate to keratin sulphate over the first few years of life
***Progressive decrease in amount of glycosaminoglycans, and changes from chondroitin sulphate to keratin sulphate over the first few years of life