Changes

==Clinical Signs==  

==Clinical Signs==  

Early clinical signs may include subtle '''behavioural and neuorological changes'''.  Sheep often have a fixed gaze, and suffer from bruxism, fine tremors, and hyperaesthesia to sound or sudden movements. Affected animals may later become exercise intolerant and develop progressive ataxia.  Sheep often find difficulty in turning, sway on their hind hindquarters and have gait abnormalities such as a high stepping gait in the forelimbs or a bunny hopping gait in the hindlimbs. Some sheep have intense pruritis that leads to compulsive rubbing, nibbling at the skin, or scraping against fixed objects.  Wool loss is typically seen over the hindquarters and lateral thorax. Lip smacking or nibbling reflex can often be elicited by scratching over the lumbar region, which is characteristic og scrapie. Significant weight loss with or without a decrease in appetite, weakness, recumbency, and death are all seen within the later stages of the disease.  

Early clinical signs may include subtle '''behavioural and neuorological changes'''.  Sheep often have a fixed gaze, and suffer from bruxism, fine tremors, and hyperaesthesia to sound or sudden movements. Affected animals may later become exercise intolerant and develop '''progressive ataxia'''.  Sheep often find difficulty in turning, sway on their hind hindquarters and have gait abnormalities such as a high stepping gait in the forelimbs or a bunny hopping gait in the hindlimbs. Some sheep have '''intense pruritis''' that leads to compulsive rubbing, nibbling at the skin, or scraping against fixed objects.  Wool loss is typically seen over the hindquarters and lateral thorax. Lip smacking or '''nibbling reflex''' can often be elicited by scratching over the lumbar region, which is characteristic og scrapie. Significant weight loss with or without a decrease in appetite, weakness, recumbency, and death are all seen within the later stages of the disease.  

==Diagnosis==

==Diagnosis==