Changes

==Introduction==

==Introduction==

'''Chronic renal failure''' is the end result of persistent, chronic renal disease - it is usually '''irreversible''' and involves the '''gradual and progressive loss of [[Nephron - Anatomy & Physiology|nephrons]]''' resulting in loss of function. Clinical signs include '''polyuria/polydipsia (PU/PD)''' and [[Uraemia|'''uraemia''']], and blood sample analysis shows [[Azotaemia|'''azotaemia''']], [[Regenerative and Non-Regenerative Anaemias|'''non-regenerative anaemia''']] and '''hyperphosphataemia'''. Often presented as 'end stage kidney' disease, on gross pathology kidneys are '''shrunken, fibrosed, pale and firm'''.

'''Chronic renal failure''' is the end result of persistent, chronic renal disease - it is usually '''irreversible''' and involves the '''gradual and progressive loss of [[Nephron - Anatomy & Physiology|nephrons]]''' resulting in loss of function. Clinical signs include '''polyuria/polydipsia (PU/PD)''' and [[Uraemia|'''uraemia''']], and blood sample analysis shows [[Azotaemia|'''azotaemia''']], [[Regenerative and Non-Regenerative Anaemias|'''non-regenerative anaemia''']] and '''hyperphosphataemia'''. Often presented as 'end stage kidney' disease, on gross pathology kidneys are '''shrunken, fibrosed, pale and firm'''.