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Reductions in renal output allow ketone bodies and glucose to increase to ever higher concentrations in the blood.  Water moves from the intracellular space to compensate for this high plasma osmolality and the alterations in cellular hydration may result in comas or seizures.  
 
Reductions in renal output allow ketone bodies and glucose to increase to ever higher concentrations in the blood.  Water moves from the intracellular space to compensate for this high plasma osmolality and the alterations in cellular hydration may result in comas or seizures.  
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The combined effects of these metabolic derangements may be life-threatening and urgent medical intervention is required.  
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The combined effects of these metabolic derangements may be life-threatening and urgent medical intervention is required.
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'''[[Diabetic Ketoacidosis]]''' provides a complete review of the condition.
    
====Chronic Disease====
 
====Chronic Disease====
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