Changes

'''Haematological''' analysis should always be performed with suspected lymphoma for staging purposes and for the recording of base-line parameters prior to the initiation of any treatment to assess the severity of any future myelosuppression. Potential abnormalities for those patients with bone marrow involvement may include [[Lymphocytosis|lymphocytosis]], [[Platelet Abnormalities#Thrombocytopaenia|thrombocytopenia]], [[Neutropenia|neutropenia]] and the presence of immature lymphoid precursors.

'''Haematological''' analysis should always be performed with suspected lymphoma for staging purposes and for the recording of base-line parameters prior to the initiation of any treatment to assess the severity of any future myelosuppression. Potential abnormalities for those patients with bone marrow involvement may include [[Lymphocytosis|lymphocytosis]], [[Platelet Abnormalities#Thrombocytopaenia|thrombocytopenia]], [[Neutropenia|neutropenia]] and the presence of immature lymphoid precursors.

Affected cats are not usually leukemic.

Affected cats and dogs are not usually leukemic.

On '''biochemistry''' abnormalities may include hypoproteinaemia, elevated hepatic enzymes and elevated [[Urea|Blood Urea Nitrogen]] /[[Creatinine|creatinine]].

On '''biochemistry''' abnormalities may include hypoproteinaemia, elevated hepatic enzymes and elevated [[Urea|Blood Urea Nitrogen]] /[[Creatinine|creatinine]], but again these will depend on the area affected. A percentage of dogs will present with hypercalcemia of malignancy (see below), affecting both total and ionized calcium and in some cases causing a secondary azotaemia.  

All cats with suspected lymphoma should be tested for '''[[FeLV]]''' and '''[[Feline Immunodeficiency Virus|FIV]]''', usually performed via enzyme-linked immunosorbent assay ([[ELISA testing|ELISA]]) available in general practice in kit form (CITE test). Virus isolation would be required for a definitive result, however this is not only more time consuming but is more expensive. An ELISA is also frequently used for the diagnosis of FIV.

All cats with suspected lymphoma should be tested for '''[[FeLV]]''' and '''[[Feline Immunodeficiency Virus|FIV]]''', usually performed via enzyme-linked immunosorbent assay ([[ELISA testing|ELISA]]) available in general practice in kit form (CITE test). False negatives are very rare but false positives can be seen depending on the sensitivity and specificity of the assay and if the diagnosis does not fit with the clinical picture, a confirmatory test should be performed such as viral isolation. Vaccination for FeLV does not lead to false positive results on the ELISA as the test looks for antigen. However, the current FIV vaccines available in the USA do not have a marker and so can lead to false positive FIV antibody SNAP tests.  

'''Paraneoplastic Syndrome'''

'''Paraneoplastic Syndrome'''