9 bytes added ,  14:52, 24 April 2012
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#C1 esterase first digests C4 to C4a and C4b and the C2 to C2a and C2b  
 
#C1 esterase first digests C4 to C4a and C4b and the C2 to C2a and C2b  
 
#*C4b binds to the antigen
 
#*C4b binds to the antigen
#C4b then binds C2b
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#C4b then binds C2a
#*C4b and C2b complex to form the enzyme C2b¯4b (C3 convertase)
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#*C4b and C2a complex to form the enzyme C2a¯4b (C3 convertase)
#C2b¯4b digests C3 into C3a and C3b.
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#C2a¯4b digests C3 into C3a and C3b.
 
#*The production of C3b can now be amplified by the same mechanism as the alternative pathway
 
#*The production of C3b can now be amplified by the same mechanism as the alternative pathway
 
#*The binding of one C1q molecule produces one C1 esterase molecule that then causes the binding of many hundreds of C4b¯2b molecules
 
#*The binding of one C1q molecule produces one C1 esterase molecule that then causes the binding of many hundreds of C4b¯2b molecules
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#*Forms C4b2¯b3b (C5 convertase)
 
#*Forms C4b2¯b3b (C5 convertase)
 
#*This activates C5 and initiates the [[#Membrane Attack Complex|membrane attack complex]] (MAC)
 
#*This activates C5 and initiates the [[#Membrane Attack Complex|membrane attack complex]] (MAC)
*All the Ca fragments (C2a, C3a, C4a, C5a)
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*Ca fragments C3a, C4a and C5a, and Cb fragment C2b
 
**Are chemotactic for [[Neutrophils|neutrophils]]  
 
**Are chemotactic for [[Neutrophils|neutrophils]]  
 
**Induce acute inflammation
 
**Induce acute inflammation
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