Changes

===Cell Death===

===Cell Death===

Neutrophils have a limited life span as they cannot synthesise protein or produce ATP through the electron transfer chain in mitochondria. They hence undergo a process called '''apoptosis''' (otherwise reffered to as ''Programmed Cell Death'' or ''Cell Suicide''). This enables the neutrophils to be cleared by tissue [[Macrophages|macrophages]], and therefore the physiological resolution of inflammation. However, in pathological conditions, where the neutrophils that have undergone apoptosis cannot be cleared as there are too few macrophages, or the pathogen is causing the death of the neutrophils, they undergo a process called '''necrosis'''. This results in the release of all of the intracellular contents, and therefore the amplification of the inflammatory response. It is these neutrophils that have undergone necrosis that forms what is known as '''Pus'''.  

Neutrophils have a limited life span as they cannot synthesise protein or produce ATP through the electron transfer chain in mitochondria. They hence undergo a process called '''apoptosis''' (otherwise reffered to as ''Programmed Cell Death'' or ''Cell Suicide''). This enables the neutrophils to be cleared by tissue [[Macrophages|macrophages]], and therefore the physiological resolution of inflammation. However, in pathological conditions, where the neutrophils that have undergone apoptosis cannot be cleared as there are too few macrophages, or the pathogen is causing the death of the neutrophils, they undergo a process called '''necrosis'''. This results in the release of all of the intracellular contents, and therefore the amplification of the inflammatory response. It is these neutrophils that have undergone necrosis that forms what is known as [[Necrosis - Pathology#Pus Formation|'''pus''']].

===In pathology===

===In pathology===