Changes

*''P. aeruginosa''

*''P. aeruginosa''

*''E. aerogenes''

*''E. aerogenes''

Bacterial cell wall endotoxins are the cause of septic shock, stimulating macrophages to release IL-1 and TNF-α at excessive levels. The condition is often fatal and symptoms include a sudden drop in blood pressure, fever, diarrhoea and blood-clotting in multiple organs.  

Bacterial cell wall endotoxins (Lipopolysaccharide) are the cause of septic shock, stimulating macrophages to release IL-1 and TNF-α at excessive, systemic levels. The condition is often fatal and symptoms include a sudden drop in blood pressure, fever, diarrhoea and blood-clotting in multiple organs.

 

===Bacterial toxic shock===

===Bacterial toxic shock===

This condition is caused by bacterial toxins known as superantigens (antigens that bind simultaneously to MHC II and the beta-V domain of the T cell receptor) that activate large numbers of T cells despite specificity. A number of bacteria have been implicated in the production of superantigens, including:

This condition is caused by bacterial toxins known as superantigens (antigens that bind simultaneously to MHC II and the beta-V domain of the T cell receptor) that activate large numbers of T cells despite specificity. A number of bacteria have been implicated in the production of superantigens, including: