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Major Histocompatability Complexes (view source)
Revision as of 10:32, 16 May 2012
, 10:32, 16 May 2012→Presentation Pathway
===Presentation Pathway===
===Presentation Pathway===
[[File:MHC Class II Presentation.png|thumb|left|200px|MHC Class II Presentation pathway - RJ Francis, RVC, 2012]]
[[File:MHC Class II Presentation.png|thumb|left|200px|MHC Class II Presentation pathway - RJ Francis, RVC, 2012]]
MHC II presents '''exogenous''' (Extracellular Fluid) peptides. Endocytosed antigen interacts with MHC II in the cytoplasm to form a complex:
MHC II presents '''exogenous''' (Extracellular fluid - ECF) peptides. Endocytosed antigen interacts with MHC II in the cytoplasm to form a complex:
*Antigen is endoycotsed from the ECF
*Antigen is endoycotsed from the ECF
*Lysosomes fuse with primary endosomes to digest the antigen to peptides
*Lysosomes fuse with primary endosomes to digest the antigen to peptides