495
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Changes
→TH1 Cells
The Langerhans cells leave the epithelium and travel via the afferent lymph flow. They are now known as '''Veiled Cells'''. Veiled cells enter the paracortical region of the [[Lymph Nodes - Anatomy & Physiology|lymph node]] where they present antigen to the T cells. They are now known as '''Interdigitating Dendritic Cells'''.
The Langerhans cells leave the epithelium and travel via the afferent lymph flow. They are now known as '''Veiled Cells'''. Veiled cells enter the paracortical region of the [[Lymph Nodes - Anatomy & Physiology|lymph node]] where they present antigen to the T cells. They are now known as '''Interdigitating Dendritic Cells'''.
==TH<sub>1</sub> Cells==
==T<sub>H</sub>1 Cells==
[[Image:TH1-macrophage.jpg|thumb|right|200px|TH-1 cells boost macrophage response - B. Catchpole, RVC 2008]]
[[Image:TH1-macrophage.jpg|thumb|right|200px|TH-1 cells boost macrophage response - B. Catchpole, RVC 2008]]
TH<sub>1</sub> cells help macrophages digest bacteria - the organisms are contained in cellular vesicles.
TH<sub>1</sub> cells help macrophages digest bacteria - the organisms are contained in cellular vesicles.
T<sub>H</sub>1 cells secrete a range of cytokines, including:
* '''IL-2''', which induces proliferation of both [[Helper_CD4%2B#Helper_CD4.2B|CD4<sup>+</sup>]] and [[Cytotoxic_CD8%2B#Cytotoxic_CD8.2B|CD8<sup>+</sup> T-cells]]. This stimulation of T cell proliferation is the main function of the TH<sub>1</sub> cell.
* '''IL-2''', which induces proliferation of both [[Helper_CD4%2B#Helper_CD4.2B|CD4<sup>+</sup>]] and [[Cytotoxic_CD8%2B#Cytotoxic_CD8.2B|CD8<sup>+</sup> T-cells]]. This stimulation of T cell proliferation is the main function of the TH<sub>1</sub> cell.
* '''Interferon gamma''' ('''IFNγ''') which activates tissue macrophages and is the principal effector mechanism in the defence against intracellular bacteria and parasites such as Mycobacteria, Brucella, Rickettsia Leishmania, Coccidia, and Babesia. IFNγ activates macrophages and stimulates them to produce enzymes triggering intracellular killing mechanisms - specifically:
* '''Interferon gamma''' ('''IFNγ''') which activates tissue macrophages and is the principal effector mechanism in the defence against intracellular bacteria and parasites such as Mycobacteria, Brucella, Rickettsia Leishmania, Coccidia, and Babesia. IFNγ activates macrophages and stimulates them to produce enzymes triggering intracellular killing mechanisms - specifically: