Changes

*Grow on Sabouraud dextrose agar

*Grow on Sabouraud dextrose agar

*Cell wall contains mycolic acids (hence slightly acid fast)

*Cell wall contains mycolic acids (hence slightly acid fast)

*''Nocardia asteroides'' found in soil and decaying vegetation - saprophytic

*''Nocardia asteroides''  

*Opportunistic infection of immunocompromised animals  

**Found in soil and decaying vegetation - saprophytic

*Infection via inhalation, wounds or teat canal; also ingestion

**Opportunistic infection of immunocompromised animals  

*Causes granulomatous lesions in animals

**Infection via inhalation, wounds or teat canal; also ingestion

*Canine nocardiosis: cutaneous pyogranulomas; [[Peritoneal cavity - inflammatory#In dogs|peritonitis]]; [[Bacterial infections#Nocardiosis|pleuritis]] and pyothorax; disseminated lesions

**Causes granulomatous lesions in animals

*Cattle: chronic mastitis; abortion

**Canine nocardiosis: cutaneous pyogranulomas; [[Peritoneal cavity - inflammatory#In dogs|peritonitis]]; [[Bacterial infections#Nocardiosis|pleuritis]] and pyothorax; disseminated lesions

*Pigs: abortion

**Cattle: chronic mastitis; abortion

*Sheep, goats, horses: wound infections; mastitis; pneumonia

**Pigs: abortion

*Survives and multiplies in macrophages

**Sheep, goats, horses: wound infections; mastitis; pneumonia

*Superoxide dismutase and catalase as well as a thick peptidoglycan wall prevent activity of phagocytes  

**Survives and multiplies in macrophages

*Chronic, progressive disease

**Superoxide dismutase and catalase as well as a thick peptidoglycan wall prevent activity of phagocytes  

*Lesions difficult to treat due to resistance of organisms to many antimicrobials (e.g. penicillins)

**Chronic, progressive disease

*Cell-mediated immunity required

**Lesions difficult to treat due to resistance of organisms to many antimicrobials (e.g. penicillins)

**Cell-mediated immunity required

*''Nocardia farcinica'' causes bovine farcy

*''Nocardia farcinica'' causes bovine farcy