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*Histotoxic clostridia cause localised lesions in tissues and may cause toxaemia
 
*Histotoxic clostridia cause localised lesions in tissues and may cause toxaemia
 
*''C. perfringens'' cause inflammatory lesions in the gastrointestinal tract and enterotoxaemias in sheep
 
*''C. perfringens'' cause inflammatory lesions in the gastrointestinal tract and enterotoxaemias in sheep
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===Characteristics===
 
===Characteristics===
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**Tetanospasmin made by bacteria replicating in damaged tissue
 
**Tetanospasmin made by bacteria replicating in damaged tissue
 
**Absorbed toxin affects neuromuscular junction distant from site of toxin production
 
**Absorbed toxin affects neuromuscular junction distant from site of toxin production
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**Neurotoxin binds irreversibly to ganglioside receptors on motor neurons and is transported to nerve cell body
 
**
 
**
  
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