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*Histotoxic clostridia cause localised lesions in tissues and may cause toxaemia
*Histotoxic clostridia cause localised lesions in tissues and may cause toxaemia
*''C. perfringens'' cause inflammatory lesions in the gastrointestinal tract and enterotoxaemias in sheep
*''C. perfringens'' cause inflammatory lesions in the gastrointestinal tract and enterotoxaemias in sheep
===Characteristics===
===Characteristics===
**Tetanospasmin made by bacteria replicating in damaged tissue
**Tetanospasmin made by bacteria replicating in damaged tissue
**Absorbed toxin affects neuromuscular junction distant from site of toxin production
**Absorbed toxin affects neuromuscular junction distant from site of toxin production
**Neurotoxin binds irreversibly to ganglioside receptors on motor neurons and is transported to nerve cell body
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