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↓=Downregulation of receptor    ↑=Upregulation of receptor
 
↓=Downregulation of receptor    ↑=Upregulation of receptor
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Changes in receptor numbers take several days to occur. The effect of these postsynaptic receptor number changes is an increase in the levels of two crucial compounds, C-amp Response Element Binding Protein (CREB) and Brain Derived Neurotropic Factor (BDNF). The end results of these presynaptic and postsynaptic changes are:
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Significant changes in receptor numbers take several weeks to occur. The effect of these postsynaptic receptor number changes is an increase in the levels of two crucial compounds, C-amp Response Element Binding Protein (CREB) and Brain Derived Neurotropic Factor (BDNF). The end results of these presynaptic and postsynaptic changes are:
    
*Increase in serotonin in the synaptic cleft.
 
*Increase in serotonin in the synaptic cleft.
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