Changes

↓=Downregulation of receptor    ↑=Upregulation of receptor

↓=Downregulation of receptor    ↑=Upregulation of receptor

Changes in receptor numbers take several days to occur. The effect of these postsynaptic receptor number changes is an increase in the levels of two crucial compounds, C-amp Response Element Binding Protein (CREB) and Brain Derived Neurotropic Factor (BDNF). The end results of these presynaptic and postsynaptic changes are:

Significant changes in receptor numbers take several weeks to occur. The effect of these postsynaptic receptor number changes is an increase in the levels of two crucial compounds, C-amp Response Element Binding Protein (CREB) and Brain Derived Neurotropic Factor (BDNF). The end results of these presynaptic and postsynaptic changes are:

*Increase in serotonin in the synaptic cleft.

*Increase in serotonin in the synaptic cleft.