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Clomipramine (view source)

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→‎Comparison of Effects and Adverse Effects for Clomipramine and Related Drugs

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Interestingly no effect has been found in those tests (so far performed) that involve conditioned fear potentiated startle responses.

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~~==Comparison of Effects and Adverse Effects for Clomipramine and Related Drugs==~~

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~~{| class="wikitable"~~

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~~! Drug !! Class !! 5-HT:NorAdrenaline Blocking ratio !! H<sub>1</sub> Blockade !! Ach (Muscarinic) Blockade~~

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~~| Amitriptyline || TCA || 1:4 || +++ || +++~~

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~~| Clomipramine || TCA || 5:1 || ++ || ++~~

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~~| Fluoxetine || SSRI || 15:1 || || +~~

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~~| Fluvoxamine || SSRI || 150:1 || || +~~

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~~| Sertraline || SSRI || 150:1 || || +~~

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|}

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The blocking ratio indicates the relative effect of the agent on reuptake of 5-HT vs. noradrenaline. Fluoxetine is 3 times more selective for 5-HT than clomipramine. Clomipramine was the first TCA whose ratio favours 5-HT reuptake inhibition, and hence its title of non-selective serotonin reuptake inhibitor (SRI).

==Use==

Jon Bowen

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