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Amitriptyline also antagonises α2-adrenoceptors, which can lead to agitation and tachycardia.

Amitriptyline also antagonises α2-adrenoceptors, which can lead to agitation and tachycardia.

TCAs can also cause loss of libido (breeding animals) and mild corneal drying. They can cause galactorrhea through increased prolactin secretion (especially in cats).

TCAs can also cause loss of libido (breeding animals) and mild corneal drying. They can cause galactorrhea through increased prolactin secretion (especially in cats). TCAs that predominantly alter noradrenaline re-uptake inhibition may predispose patients to sudden and violent emotional reactions including aggression and should be used with care in aggression cases.

 

Finally, those TCAs that depend upon NorAdrenaline reuptake inhibition for a part of their effect are sometimes associated with explosive emotional reactions including aggression. They should be used with some care.

There are large differences in selectivity of re-uptakje inhibitor drugs, as can be seen in the following table.

There are large differences in selectivity of re-uptakje inhibitor drugs, as can be seen in the following table.